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Cystic Fibrosis
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TOPIC: CYSTIC FIBROSIS
LENGTH: 1:57
TRACK 1: Narration
TRACK 2: Interviews and Nat Sound
PROMO:
FIND OUT HOW GENETIC THERAPY MAY ONE DAY CURE CYSTIC FIBROSIS. (:04)
STUDIO INTRO:
CYSTIC FIBROSIS IS A GENETIC DISEASE WHERE A MALFUNCTIONING GENE PRODUCES A PROTEIN THAT MAKES IT DIFFCULT FOR THE BODY TO REGULATE SALT AND THAT CAN PRODUCE THICK SECRETIONS ESPECIALLY IN THE LUNGS. NOW RESEARCHERS AT THE UNIVERSITY OF ALABAMA AT BIRMINGHAM ARE THE FIRST IN THE NATION TO BEGIN REVOLUTIONARY NEW METHOD OF GENE THERAPY FOR CYSTIC FIBROSIS. (:25)
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NAT SOUND |
“Let’s try to teach you how to program some numbers on your phone. OK? OK..” |
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NARRATION/VO |
JIM HUNT IS 32 YEARS OLD . . . TONY ARENO IS 38. BOTH OF THESE MEN HAVE CYSTIC FIBROSIS AND BOTH ARE AMONG THE FIRST PATIENTS IN THE UNITED STATES TO BE INVOLVED IN A PROMOSING NEW GENE STUDY. UNLIKE MANY OF THEIR FELLOW PATIENTS, BOTH OF THEM HAVE BEATEN THE ODDS. MOST PATIENTS DON’T MAKE IT PAST THEIR THIRIETH BIRTHDAY.(:21) |
CG
Jim Hunt
CF Patient
IN: :26
OUT: :32 |
“When I was diagnosed I was told on April Fool’s Day and I was 15 years old at that time the life expectancy was 16 which basically gave me two months to live. At least it was in my mind. And every year they seem to move the years back.” |
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NARRATION/VO |
RESEARCHRS START BY CHECKING HEIGHT AND WEIGHT. THEN BEFORE AND AFTER EXERCISE, STUDENTS TAKE A BREATHING TEST TO SEE HOW FORCEFULLY THEY CAN BLOW THE AIR OUT OF THEIR LUNGS. (:09) |
CG
Eric Sorscher, MD
Director, CF Research
Center
IN: :40
OUT: :45 |
“Most of the morbidity and mortality occurs in the lungs with thick secretions that cause blockage and decrease function in the lungs and in breathing and ultimately death.” |
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NAT SOUND |
Laboratory |
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NARRATION/VO |
DOCTOR SORSCHER ( SORE-sure) AND HIS COLLEAGUES AT THE UNIVERSITY OF ALABAMA AT BIRMINGHAM ARE TAKING A NORMAL FUNCITONING COPY OF THE C-F GENE AND PUTTING IT INTO A “CARRIER”.THAT CARRIER WILL THEN DELIVER IT INTO THE D-N-A OF A MALFUNCTIONING CELL. (:14) |
CG
Eric Sorscher, MD
Director, CF Research
Center
IN: 1:07
OUT: 1:15 |
“The particular carrier that we use is called a lipisome. A lipisome is easy to think of as a soap bubble. The soap bubble coats the gene and the lining inside the lungs is also made of material like soap bubbles, so when the gene coated in this soapy substance reaches the cell, it can fuse and the gene can be directly innoculated into the cell.” |
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NARRATION/VO |
SO FAR, THIS GENE THERAPY HAS PROVEN TO BE SAFE AND EFFECTIVE. BUT, SAYS DOCTOR SORSCHER, MORE WORK NEEDS TO BE DONE. (:08) |
CG
Eric Sorscher, MD
Director, CF Research
Center
IN: 1:37
OUT: 1:42 |
“Although we’re at an early stage and though this is not therapy just an approach to therapy, there’s a lot of reason to be optimistic.” |
CG
Tony Areno
CF Patient
IN: 1:45
OUT: 1:50 |
“Like the study Dr. Sorscher done with me . . if that leads to somebody else to leads to a cure to this disease, more power to him.” |
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NARRATION/VO |
FOR U-A-B BROADCAST NEWS, THIS IS CAROLYN DUNLAP REPORTING. (:04) |
STUDIO TAG:
ABOUT THIRTY THOUSAND PEOPLE IN THE UNITED STATES HAVE CYSTIC FIBROSIS. BUT MANY MORE ARE CARRIERS. THE ONLY WAS TO KNOW IS THROUGH GENE TESTING. (:11)
CHYRONS
Jim Hunt
CF Patient
Tony Areno
CF Patient
Eric Sorscher, MD
Director, UAB Cystic Fibrosis (CF) Research Center
UAB Hemotologist/Oncologist
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PRODUCER |
Please forward all inquiries received for more information on this report to:
Andrea Reiber
UAB Broadcast News
701 20th Street South, AB 1320
Birmingham, AL 35294-0113
1-800-822-9091 or E-Mail: amc@UAB.EDU
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