Awards/Recognitions:

National Advisory Council of the Center for Alternative and Complementary Medicine, 2007-2010, Plenary speaker, Tradition to Technology, Saskatoon, Saskatchewan, Canada, 2007; Plenary Speaker, PHENRIG Symposium, FASEB, Washington, DC, 2007; Steering Committee, Nutrigenomics Symposium, Auckland, New Zealand, 2006; Chair, Proteomics session at the AACR Meeting, Philadelphia, 2005; Life time Achievement Award, 5th International Symposium on the Role of Soy in the Prevention and Treatment of Chronic Disease, Orlando, FL (2003); Chair, 4th International Symposium on the Role of Soy in the Prevention and Treatment of Chronic Disease, San Diego, CA (2001); Visiting Professor, Wayne State University Karmanos Cancer Center (1999); Keynote Speaker, Australian Society for Experimental Pathology (1998); Visiting Professor, University of Hawaii Cancer Research Center (1995); Visiting Professor, Harvard University (1991); Wellcome Trust Travel Fellowships (1974, 1975)

Current Research Support:

Comprehensive Cancer Center Mass Spectrometry Shared Facility, (E. Partridge, PI) S. Barnes, Director, Mass Spectrometry Core Facility, 2005-2010.

NIH/ODS P50 AT00477, "Botanicals center for age-related diseases" (Connie M. Weaver, PI,) Project 3: Singlet oxygen, polyphenols and lens proteins", S. Barnes, PI, 2005-2010.

NIH/ODS P50 AT00477, "Botanicals center for age-related diseases (Purdue-UAB)" (Connie M. Weaver, PI) "Core D: In vivo bioavailability", S. Barnes PI, 2005-2010.

NIH/ODS P50 AT00477, "Botanicals center for age-related diseases (Purdue-UAB)" (Connie M. Weaver, PI) Project 1; Phytoestrogens and osteoporosis", S. Barnes, Investigator, 2005-2010.

NIH P01 HL070610 Project 4: "Mitochondria and protection by ethanol and polyphenols" (V Darley-Usmar, Project leader, FM Boyse, PI), S. Barnes, Co-investigator, 2003 - 2008.

NIH R01 HL58031 "Nitrosative and oxidative signaling in Endothelial Cells" (VM Darley-Usmar, PI), S. Barnes, Co-investigator, 2003-2008.

NIH/NCI U54 CA100949, "Center for Nutrient-Gene Interaction in Cancer Prevention", S. Barnes, PI, 2003-2008.

NIH/NIAMS P30 AR050948, "Dermatology Research Center", (PI: Craig Elmets), S. Barnes, Proteomics Core Director, 08/01/04 - 07/31/09.

NIH/NIDDK 1 R01 DK-46390 "Amino acid conjugation of bile acids", S. Barnes, PI, 20% effort, 09/01/04-07/31/08.

NIDDK 1 P30 DK74038, "UAB Recessive PKD Research and Translational Core Center - Core E Proteomics" (Lisa Guay-Woodford, PI), S. Barnes Proteomics Core co-Director, 10/01/05-9/30/10.

Alabama Eyesight Foundation, “Estrogen-mediated regulation of the expression and distribution of the a-crystallin lens protein”, S. Barnes, PI, 5% effort, 07/01/07-06/30/09.

NCCAM 1 R01 AT004294, “Curcumin reverses tumor exosomes-mediated inhibition of myeloid differentiation” (Huang-Ge Zhang, PI), S. Barnes, investigator, 5% effort, 07/01/07-06/30/12.

Selected publications

2007

Prasain, J.K., Reppert, A., Jones, K., Moore, D.R., II, Barnes, S., and Lila, M.A. Isoflavones in Pueraria lobata cell cultures. Phytochemical Analysis, 18: 50-59, 2007.

Cheong, J.M.K., Martin, B.R., Jackson, G.J., Elmore, D., McCabe, G.P., Nolan, J.R., Barnes, S., Peacock, M., and Weaver, C.M. Soy isoflavones do not affect bone resorption in postmenopausal women: A dose response study using a novel approach with ⁴¹Ca. Journal of Clinical Endocrinology & Medicine, 92: 577-582, 2007.

Prasain, J., Peng, N., Acosta, E., Moore, D.R., Arabshahi, A., Meezan, E., Barnes, S., Wyss, J.M. Pharmacokinetic study of puerarin in rat serum by liquid chromatography tandem mass spectrometry. Biomedical Chromatography, 21: 410-417, 2007.

Ye, Y., Celia Quijano, C., Robinson, K.M., Ricart, K.C., Strayer, A.L., Shacka, J.J., Kirk, M., Barnes, S., Radi, R., Beckman, J.S., Estévez, A.G. Tyrosine nitration in peroxynitrite-induced apoptosis of motor neurons and PC12 cells. Journal of Biological Chemistry, 282: 6324-6337, 2007.

Chacko, B.K., Chandler, R.T., D’Alessandro, T.L., Mundhekar, A., Khoo, N.K., Botting, N., Barnes, S., Patel, R.P. Anti-inflammatory effects of isoflavones are dependent on flow and human endothelial cell PPARg. Journal of Nutrition, 137: 351-356, 2007.

Lee, S.A., Wen, W, Xiang, Y.B., Barnes, S., Liu, D.K., Cai, Q., Zheng, W., Shu, X.O. Assessment of dietary isoflavone intake among middle age Chinese men. Journal of Nutrition, 137: 1011-1016, 2007.

Sites, C.K., Cooper, B.C., Toth, M.J., Gastaldelli, A.,Arabshahi, A. Barnes, S. Effect of a Daily Supplement of Soy Isoflavones on Body Composition and Insulin Secretion in Postmenopausal Women. Fertility and Sterility, in press, 2007.

Brand, J.P.L., Beasley, T.M., Page, G.P., Bartolucci, A.A., Kim, K., Barnes, S., and Allison, D.B. An adaptive weighted p-value algorithm for more powerful multiplicity control in high dimensional biology: an application to inferential testing in microarray data analysis. Bioinformation, 1:384, 2007.

Styles, N.A, Falany, J.L., Barnes. S., Falany. C.N. Quantification and Regulation of the Subcellular Distribution of Bile acid CoA:amino acid N-acyltransferase Activity in Rat Liver. Journal of Lipid Research, 48: 1305-1315, 2007.

Zhang, H-G., Kim, H., Liu, C., Yu, S., Wang, J, Zhang, L., Grizzle, W.E., Kimberly, R.P., and Barnes, S. Curcumin reverses breast tumor exosomes mediated immune suppression of NK cell tumor cytotoxicity. Biochimica et Biophysica Acta, accepted for publication, 2007.

Eliuk S.M., Renfrow, M.B., Shonsey, E., Kirk, M.C., Barnes, S., Kim, H. Active site modification of cytosolic creatine kinase by 4-hydroxy-2-nonenal correlates with reduction in activity. Chemical Research in Toxicology, accepted for publication, 2007.

Ashwell M., Stone, E., Mathers, J., Barnes, S., Compston, J., Francis, R.M., Key, T., Cashman, K.D., Cooper, C., Khaw, K.T., Lanham-New, S., Macdonald, H., Prentice, A., Shearer, M. and Stephen, A. Nutrition and bone health projects funded by the UK Food Standards Agency: have they helped to inform public health policy? British Journal of Nutrition, accepted for publication, 2007.

2006

Huang, C.M., Wang, C.C., Kawai, M., Barnes, S., and Elmets, C.A. Surfactant sodium lauryl sulfate enhances skin vaccination: Molecular characterization via a novel technique using ultrafiltration capillaries and mass spectrometric proteomics. Mol Cell Proteomics 5: 523-530, 2006.

Horn-Ross, P.L., Barnes, S., Lee, V.S., Collins, C.N., Reynolds, P., Lee, M.M., Stewart, S.L., Canchola, A.J., Wilson, L., Jones, K. Reliability and Validity of an Assessment of Usual Phytoestrogen Consumption. Cancer Causes and Control, 17; 85-93, 2006.

Landar, A., Giles, N.M., Oh, J-Y., Foxwell, A., Kirk, M., Barnes, S., and Darley-Usmar, V.M. A sensitive method for the quantitative measurement of protein thiol modification in response to oxidative stress. Free Radical Biology and Medicine, 40: 459-468, 2006.

Liu, C., Yu, S. Zinn, K., Wang, J., Zhang, L., Jia, Y., Kappes, J.C., Barnes, S., Kimberly, R.P., Grizzle, W.E. and Zhang, H-G. Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function. Journal of Immunology, 176, 1375-1385, 2006.

Sarkar, P., Sarkar, S., Ramesh, V., Hayes, B.E., Thomas, R.L., Wilson, B.L., Kim, H., Barnes, S., Kulkarni, A., Pellis, N. and T. Ramesh, G.T. Proteomic analysis of mice hippocampus in simulated microgravity environment. Journal of Proteome Research, 5: 548-553, 2006.

Kim, H., Deshane, J., Barnes, S., and Meleth, S. Proteomics analysis of the actions of grape seed extract in rat brain: Technologic and biologic implications for the study of the actions of psychoactive compounds. Life Sciences, 78: 2060-2065, 2006.

Kim, K., Page, G.P., Beasley, T. M., Barnes, S., Scheirer, K.E., and Allison, D.B. A proposed metric for assessing the measurement quality of individual microarrays. BMC Bioinformatics, 7: 35, 2006.

Barnes, S., Prasain, J.K., Wang, C-C., Moore, D.R., II. Applications of LC-MS in the study of the uptake, distribution, metabolism and excretion of bioactive polyphenols from dietary supplements. Life Sciences, 78: 2054-2059, 2006.

Hsu, H.C., Zhou, T., Kim, H., Barnes, S., Yang, P., Wu, Q., Zhou, J., Freeman, B.A., Luo, M., Mountz, J.D. Production of a novel class of polyreactive pathogenic autoantibodies in BXD2 mice causes glomerulonephritis and arthritis. Arthritis & Rheumatism 54: 343-355, 2006.

Barnes, S. In the postgenomic era, can high-dimensional analyses deliver the answers we're looking for? Journal of Nutrition 136: 2709S-2710S, 2006.

Prasain, J.K., Xu, J., Kirk, M., Smith, M., Sfakianos, J., and Barnes, S. Differential biliary excretion of genistein metabolites following intraduodenal and intravenous infusion of genistin in female rats. Journal of Nutrition, 136:2975-2979, 2006.

2005

Shonsey, E, Wheeler J., Johnson, M., He, D., Falany, C.N., Falany, J., and Barnes, S. Synthesis of bile acid CoA thioesters in the amino acid conjugation of bile acids. Methods in Enzymology, H. Sies, ed., volume 400, Chapter 21, pp 360-373, 2005.

Shonsey, E, Sfakianos, M., Johnson, M., He, D., Falany, C.N., Falany, J., Merkler, D., and Barnes, S. Bile acid CoA:amino acid N-acyltransferase in the amino acid conjugation of bile acids. Methods in Enzymology, H. Sies, ed., volume 400, Chapter 22, pp 374-394, 2005.

D’Alessandro, T., Boersma, B.J., Peterson, T.G., Sfakianos, J., Prasain, J.K., Patel, R., Darley-Usmar, V.M., Botting, N., Barnes, S. Metabolism of phytoestrogen conjugates, Methods in Enzymology, H. Sies, ed., volume 400, Chapter 19, 316-342, 2005.

Huang, C.M., Wang, C.C., Kawai, M., Barnes, S., and Elmets, C.A. Surfactant sodium lauryl sulfate enhances skin vaccination: Molecular characterization via a novel technique using ultrafiltration capillaries and mass spectrometric proteomics. Mol Cell Proteomics, 5: 523-530, 2005.

Allison, D.B., Cutter, G., Poehlman E.T., Moore, D.R. II, Barnes, S. Exactly which synephrine alkaloids does Citrus Aurantium (bitter orange) contain? International Journal of Obesity, 29:443-446, 2005.

Cai^, J., Zhao, Y., Glasier, J., Cullen, D., Barnes, S., Turner, C., and Weaver, C. Comparative effect of soy protein, soy isoflavones and 17b-estradiol on bone metabolism in adult ovariectomized rats. Journal of Bone and Mineral Research, 20: 828-839, 2005.

Prasain JK, Moore DR, Barnes S, van Kuijk FJGM. Electrospray Tandem Mass Spectrometric Analysis of Carotenoids and their Oxidation Products. Journal of Mass Spectrometry, 40: 916-923, 2005.

Hedlund, T.E., Maroni, P.D., Ferucci, P.G., Dayton, R., Barnes, S., Jones, R., Moore, D.R., Ogden, L.G., Wähälä, K., Sackett, H.M, and Gray, K.J. Long-term dietary habits influence soy isoflavone metabolism in caucasian men: selective accumulation of isoflavonoids within prostatic fluid. Journal of Nutrition, 135: 1400-1406, 2005.

Uppala, P.T., Roy, S.K., Tousson, A., Barnes, S., Uppala, G.R., and Eastmond, D.A. Induction of cell proliferation and hyperploidy/polyploidy in the mammary cells of DDT- and DMBA-treated pubertal rats. Environmental and Molecular Mutagenesis, 46, 43-52, 2005.

Chacko, B.K., Robert Chandler, R.T., Mundhekar, A., Pruitt, H.M., Kucik, D.F., Kevil, C.G., Barnes, S., Patel, R.P. Revealing anti-inflammatory mechanisms of soy-isoflavones by flow: modulation of leukocyte-endothelial cell interactions. American Journal of Physiology, 289: H908-H915, 2005.

Yang, X., Wang, J., Liu, C., Grizzle, W.E., Yu, S., Zhang, S., Barnes, S., Koopman, W.J., Mountz, J.D., Kimberly, R.P., and Zhang, H-G. Cleavage of p53-vimentin complex enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of rheumatoid arthritis synovial fibroblasts. American Journal of Pathology, 167: 705-719, 2005.

Meezan, E., Meezan, E.M., Jones, K., Moore II, D.R., Barnes, S., and Prasain, J.K. Contrasting effects of the isoflavones glucosides puerarin and daidzein on glucose metabolism in mice. Journal of Agricultural and Food Chemistry, 53: 8760-8767, 2005.

Zakharkin S.O., Kim, K., Mehta, T., Chen, L., Barnes, S., Scheirer, K.E., Parrish, R.S., Allison, D.B., and Page, G.P. Sources of variation in Affymetrix microarray experiments. BMC Bioinformatics, 6:214, 2005.