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Assistant Professor of Medicine
Division of Pulmonary, Allergy & Critical Care Medicine
1530 3rd Avenue So, THT-422
University of Alabama at Birmingham
Birmingham, AL 35294
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Brief Bio
Dr. Gang Liu completed his degree in Dental Medicine at China Medical University in 1994 and his PhD in Oral Biology at Wuhan University in 1999. He moved to the United States and in 2001 completed a postdoctoral fellowship at the Institute of Molecular Medicine and Genetics at the Medical College of Georgia. Following completion of his fellowship, he came to the University of Alabama at Birmingham in 2001 and completed a second fellowship in the Dept of Cell Biology under the mentorship of Dr. Xinbin Chen. He spent the next 3 years in the Dept of Cell Biology as a research associate. In 2006, Dr. Liu was appointed to the faculty at the rank of Assistant Professor Medicine in the Division of Pulmonary, Allergy, and Critical Medicine.
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Research Interests
Dr. Liu's research focuses on the roles of microRNAs in pulmonary inflammation, hypertension, and fibrosis. The goals are: to identify specific microRNAs that are involved in these pulmonary diseases; to determine the mechanisms by which specific microRNAs regulate the pathogenesis and progression of these diseases; and to explore the therapeutic potentials of specific microRNAs in treating pulmonary diseases.
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Key Publications
Liu G*, Friggeri A, Yang Y, Milosevic J, Ding Q, Thannickal VJ, Kaminski N, Abraham E. miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med 2010; In press
Liu G, Friggeri A, Yang Y, Park YJ, Tsuruta Y, Abraham E. miR-147, a microRNA that is induced upon Toll like receptor stimulation, regulates macrophage inflammatory responses. Proc Natl Acad Sci USA 2009;106(37):15819-24
Liu G and Chen X. DNA polymerase h, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation. Mol Cell Biol 2006; 26(4):1398-413
Liu G, Nozell S, Xiao H, and Chen X. DNp73b is active in transactivation and growth suppression. Mol Cell Biol 2004; 24(2):487-501
Liu G and Chen X. The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis. Oncogene 2002; 21(47):7195-7204
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