xili@uab.edu
1720 7th Avenue South
Sparks Center, 1075
Birmingham, AL 35294
Phone: (205)934-1169
Fax: (205)934-2500
Specialty: Adult Psychiatry
Hospital Affiliations: UAB Hospital
Faculty Title: Associate Professor & Director of Behavioral Neurobiology
School of Medicine: Capital University of Medical Sciences, 1986
Internship: University of Alabama Hospital From 1997 To 1998
Residencies: University of Alabama Hospital From 1998 To 2001
Certifications: American Board of Psychiatry & Neurology
Specialty: Mood disorders, including major depressive and bipolor disorders.
Education:
• Capital University of Medical Science, M.D., 1978-1986, Medicine
• University of Alabama at Birmingham, Ph.D., 1986-1992, Pharmacology
• University of Alabama at Birmingham, Postdoctoral Research, 1992-1994, Psychiatry and Behavioral Neurobiology
• University of Alabama at Birmingham, Residency Training, 1997-2001, Psychiatry
Academic Appointments with UAB:
• Psychiatry and Behavioral Neurobiology, Associate Professor, Director of Behavioral Neurobiology, UAB
• Department of Cell Biology, 2nd faculty appointment, UAB
• Department of Neurobiology, 2nd faculty appointment, UAB
• Pharmacology and Toxicology, 2nd faculty appointment, UAB
• Neuroscience Graduate Program, Teaching appointment, UAB
• University of Alabama, Health Service Foundation, Staff Physician
Clinical Credential:
• Staff Physician: Adult Psychiatry
• Hospital Affiliations: UAB Hospital
• Certifications: American Board of Psychiatry & Neurology
• Specialty: Mood disorders - major depressive disorder and bipolar disorder.
Research Interests:
• Serotonin- and neurotrophin-regulated signal transduction, and downstream protein kinases, transcription factors, and gene expression
• Glycogen synthase kinase-3, its pharmacological regulation and impact in animal behaviors
• FoxO family transcription factors and their roles in the neurotrophin signaling pathways
• Translational research in the neurobiology, diagnosis, and pharmacological treatment of mood disorders, including bipolar disorder and major depressive disorder
Research team:
• Abby Polter, Graduate Student
• Sufen Yang, Research Assistant
• Ligong Chen, PhD, Research Associate
• Office of Psychiatry Research
Recent Publications:
• Li, X., Friedman, A.B., Roh, M.S., and Jope, R.S. Anesthesia and postmortem interval profoundly influence the regulatory serine-phosphorylation of GSK3 in mouse brain. J Neurochem, 92:701-704, 2005
• Li, X., May, R.S., Tolbert, L.C., Jackson, W.T., Flournoy, J. Baxter, Jr. L.R., Risperidone vs Haloperidol Augmentation in Selective Serotonin Reuptake Inhibitor-Refractory Obsessive-Compulsive Disorder. J Clinical Psychiatry, 66:736-743, 2005.
• Styles, N.B., Zhu, W., and Li, X. Regulation of Bim by Muscarinic Receptor Activation via Protein Kinase C-mediated Phosphorylation. Neurochemistry International, 47:519-527, 2005
• De Sarno, P., Bijur, G.N., Zmijewska,A.A., Li,X., and Jope, R.S. Regulation of glycogen synthase kinase-3β phosphorylation in vivo by cholinergic stimulation and NMDA receptor blockade, two therapeutic strategies for Alzheimer's disease. Neurobiology of Aging, 27:413-422, 2006
• Li, X., Rosborough, K., Friedman, A.B., Zhu, W., Roth, K.A., Regulation of mouse brain glycogen synthase kinase-3 by atypical antipsychotics. International J. Neuropsychopharmacology, 10:7-19, 2007
• Li, X., Friedman, A.B., Zhu, W., Wang, L., Boswell, S., May, R.S., Davis, L.L., Jope, R.S. Lithium regulates glycogen synthase kinase-3ƒÒ in human peripheral blood mononuclear cells, Biological Psychiatry, 61:216-222, 2007
• Mao, Z., Liu, L., Zhang, R., Li, X., Regulation of FoxO3a activity by lithium - new insight into the transcriptional target of mood disorder treatment. Biological Psychiatry, 62(12):1423-30, 2007
• Davis, L. L., Li, X., Bartolucci, A., Williford, R., Lowe, J., Switching from Divalproex Delayed-Release to Divalproex Extended-Release in Patients with Bipolar Disorder. J Clinical Psychiatry, 68(10):1546-51, 2007
• Reeves, H., Batra, S., May, R.S., Zhang, R., Dahl, D.C., Li, X. Efficacy of risperidone augmentation to antidepressants in the management of suicidality in major depressive disorder: A randomized, double-blind, placebo-controlled pilot study. J Clinical Psychiatry, 69(8):1228-36, 2008
• Polter, A., Yang, S., Zmijewska, A.A., Van Groen, T., Paik, J-H, DePinho, R.A., Peng, S.L., Jope, R.S., and Li, X., FoxO Transcription Factors in Brain - Regulation by Antidepressants and Behavioral Manifestation. Biological Psychiatry, in press, 2008