Adrienne C. Lahti, M.D.
alahti@uab.edu
Neuroimaging and Translational Research Laboratory
Sparks Center, suite 501
1720 7th Avenue South
Birmingham, Alabama
Education
Dr Lahti received her MD degree from the University of Liege (Belgium). She completed her internship and residency training in Psychiatry at the University of Michigan and a Fellowship in Schizophrenia Research at the Maryland Psychiatric Research Center in Baltimore, MD.
Academic Appointments with UAB
- Associate Professor, Department of Psychiatry and Behavioral Neurobiology
- Scientist, Civitan International Research Center
- Scientist, UAB Center for the Development of Functional Imaging
- Scientist, UAB Alzheimer's Disease Research Center
- Scientist, UAB Comprehensive Neuroscience Center
Previous Academic Appointments
- 1992-2006 Faculty, Maryland Psychiatric Research Center, University of Maryland, Baltimore, MD.
Research Interests
- Use of multimodal brain imaging techniques (PET, fMRI, MR Spectroscopy) to study the neuropathology of schizophrenia and bipolar disorder and to evaluate the effects of psychotropic drugs on brain function and biochemistry.
- Translational work aiming at bridging human brain imaging and postmortem studies.
People in the lab:
- David White - Program Coordinator
- Rebecca Jones, M.D. - Chief Resident, Dept. Psychiatry and Behavioral Neurobiology
- Kathy Avsar - Graduate Student, Dept. Psychology
- Mark Bolding - Graduate Student, Dept. Vision Sciences
- Meredith Reid -Graduate student, Dept. Biomedical Engineering
- Tiffany Betts - Undergraduate Student, Dept. Psychology
- Shirley Townsend - Administrative Assistant
Publications
Roberts, RC, Roche JK, Conley RR, Lahti AC. Dopaminergic synapses in the caudate of subjects with schizophrenia: relationship to treatment response. In Press, Synapse.
Artaloytia, J.F.; Arango, C.; Lahti, A.C.; Sanz, J.; Pascual, A.; Cubero, P.; Prieto, D.; Palomo, T.: Negative signs and symptoms secondary to antipsychotics: a double-blind randomized trial of a single dose of placebo, haloperidol, and risperidone in healthy volunteers. American Journal of Psychiatry,163: 488-93, 2006.
Lahti, A.C., Weiler, M.A., Holcomb, H.H., Tamminga, C.A., Carpenter, W.T., McMahon, R.: Correlations between rCBF and symptoms in two independent cohorts of drug free patients with schizophrenia. Neuropsychopharmacology, 31: 221-30, 2006.
Parwani, A., Weiler, M.A., Blaxton, T.A., Warfel, D., Hardin, M., Lahti, A.C. The effects of a subanesthetic dose of ketamine on verbal memory in normal volunteers. Psychopharmacology, 183: 265-74, 2005.
Holcomb, H.H., Lahti, A.C., Medoff, D.R., Cullen, T, Tamminga, C.A.: Effects of non-competitive NMDA blockade on regional cerebral blood flow in schizophrenia limbic cortex. Neuropsychopharmacology, 30: 2275-82, 2005.
LaPorte, D.J., Blaxton, T.A., Michaelidis, T., Robertson, D.U., Weiler, M.A., Tamminga, C.A ., Lahti, A.C. : Subtle effects of ketamine on memory when administered following stimulus presentation. Psychopharmacology, 180: 385-90, 2005.
Lahti, A.C., Weiler, M.A., Medoff, D.R., Tamminga, C.A., Holcomb, H.H.: Functional effects of single dose first and second generation antipsychotic administration in subjects with schizophrenia. Psychiatry Research: Neuroimaging, 139; 19-30, 2005.
Holcomb, H.H. Parwani, A., McMahon, R.P., Medoff, D.R., Frey, K., Lahti, A.C., Tamminga, C.A.: Parametric study of accuracy and response time in schizophrenia persons making visual or auditory discriminations. Schizophrenia Research, 127: 207-216, 2004
Lahti, A.C., Holcomb, H.H., Weiler, M.A., Medoff, D.R., Frey, K.N., Hardin, M., Tamminga, C.A. Clozapine but not haloperidol re-establishes normal task-activated rCBF patterns in schizophrenia within the anterior cingulate cortex. Neuropsychopharmacology, 29(1): 171-8, 2004
Tamminga, C.A., Lahti, A.C., Medoff, D.R., Gao X., Holcomb, H.H.: Evaluating glutamatergic transmission in schizophrenia. Ann NY Acad Sci, 1003: 113-118, 2003
Lahti, A.C., Holcomb, H.H.: Schizophrenia, VIII: Pharmacologic models. Am J Psychiatry, 160(12): 2091, 2003
Lahti, A.C., Holcomb, H.H., Weiler, M.A., Medoff , D.R., Tamminga, C.A.: Functional effects of antipsychotic drugs: comparing clozapine with haloperidol. Biological Psychiatry, 53(7): pp 601-608, 2003
Avila, M.T., Weiler, M.A., Lahti, A.C., Tamminga, C.A., Thaker, G.K.: Ketamine and leading saccades during pursuit. American Journal of Psychiatry, 159: 1470-1470, 2002
Lahti, A.C., Holcomb, H.H., Medoff, D.R., Weiler, M.A., Carpenter, W.T. Jr., Tamminga, C.A.: Altered regional cerebral blood flow patterns in schizophrenia with primary negative symptoms during an effortful recognition task. American Journal of Psychiatry, 158; 1797-1808, 2001
Medoff, D. R., Holcomb H.H., Lahti A.C., Tamminga, C.A.: Probing the human hippocampus using rCBF: contrasts in schizophrenia. Hippocampus, 11: 543-550, 2001
Lahti, A.C., Weiler, M.A., Michaelidis, T., Parwani, A., Tamminga, C.A.: Effects of ketamine in normal and schizophrenic volunteers. Neuropsychopharmacology, 25 (4): pp 455-467, 2001
Holcomb, H.H., Lahti, A.C., Medoff, D.R., Weiler, M.A., Tamminga, C.A.: Serial regional cerebral blood flow measures demonstrate pharmacodynamic ketamine effects. Neuropsychopharmacology, 25 (2): pp 165-172, 2001
Lahti, A.C., Warfel, D., Michaelidis, T., Weiler, M.A., Frey, K., Tamminga, C.A.: Long-term outcome of patients who receive ketamine during research. Biological Psychiatry, 49 (10): 869-75, 2001
Weiler, M.A. Thaker, G.K., Lahti, A.C., Tamminga, C.A.: Ketamine effects on eye movements. Neuropsychopharmacology, 23:645-653, 2000.
Holcomb, H.H., Lahti, A.C., Medoff, D.R., Weiler, M.A., Tamminga, C.A.: Brain activity patterns in schizophrenic and normal volunteers during a matched performance Auditory Recognition Task. American Journal of Psychiatry, 157:1634-45, 2000.