Dr. Barton L. Guthrie received his B.S. in psychology, followed by an M.D. degree from the University of Alabama at Birmingham in 1980. Dr. Guthrie then pursued post-doctoral studies in the Department of Physiology and Biophysics, at UAB. Subsequently, he trained in neurosurgery at the Mayo Clinic, followed by a fellowship at Stanford University. Between 1988-1992, Dr. Guthrie was an assistant professor at the George Washington University, before finally arriving to the UAB Division of Neurosurgery in 1993. He currently serves as the Director of the UAB Gamma Knife and Radiosurgery Center, and Director of Computer-Assisted Neurosurgery (CANS) at UAB.
A board-certified diplomat of the AANS, Dr. Guthrie has served on several editorial boards, including the Journal of Computer-aided Surgery, and the Journal of Radiosurgery. Additionally, he has served in leadership roles within the Neurosurgical Society of Alabama, and the Southern Neurosurgical Society.
Throughout the years, Dr. Guthrie has led a career of innovation. He holds several patents for technology related to image-guided surgery, and was co-founder of Emageon, a now publicly traded company on NASDAQ. His original work with Emageon, pioneered the era of medical image viewing on the standard desktop computer. This work now resides in a permanent collection at the Smithsonian Museum of American History, in Washington D.C.
Dr. Guthrie has numerous research interests, and directs several clinical investigation protocols, including the optimization of Deep Brain Stimulation (DBS) for Parkinson's disease and other movement disorders. He specializes in the treatment of movement disorders, surgery and radiosurgery of brain tumors, in addition to general neurosurgery practice.
Clinical research for patient care: Dr. Guthrie's research and clinical interests center on mechanisms of brain function, treatment of movement disorders, and treatment of brain tumors. He has over 50 publications in journals such as Science, Brain, Journal of Comparative Neurology, Journal of Stereotactic and Functional Neurosurgery, and Neurosurgery. His active clinical trials include developing a new Deep Brain Stimulator System to treat movement disorders (St. Jude, Inc), neurosurgical delivery of gene therapy for the treatment of Parkinson's and Alzheimer's disease (Ceregene, Inc, Alzheimer's Disease Cooperative Study Group).
Dr. Guthrie sees patients at the Kirklin Clinic on Tuesdays and Thursdays. Information about referrals and appointments can be made by calling 205-934-8136.
Featured Publications
Sparks DL, Holland R, Guthrie BL. Size and distribution of movement fields in the monkey superior colliculus. Brain Research 113:22-34, 1976.
Guthrie BL, Porter JD, Sparks DL. Corollary discharge provides eye position information to the occulomotor system. Science 221:193-195, 1983.
Guthrie BL, Ebersold MJ, Scheihtauer BW. Meningeal hemangiopericytoma: Histopathological features, treatment, and long-term follow-up of 44 cases. Neurosurg, 25: 514-522, 1989.
Lewis RF, Zee DS, Goldstein HP, Guthrie BL. Proprioceptive and retinal afference modify postsaccadic ocular drift. J Neurophysiol 82:551-63, 1999.
Guthrie BL, et al. The digital image and communications in medicine (DICOM) archive is a dynamic component of a clinician image-related workflow solution. J Digit Imaging 14(Suppl 1):190-3, 2001
Guthrie BL, et al. Support of clinician image-related workflow by a user-edited web-based patient list manager. J Digit Imaging 14 (Suppl 1): 140-2, 2001
Walker HC, Watts RL, Guthrie S, Wang D, Guthrie BL. Bilateral effects of unilateral subthalamic deep brain stimulation on Parkinson disease at 1 year. Neurosurgery 65(2):302-9, 2009.
Shenai MB, Walker HC, Watts RL, Guthrie SL, Guthrie BL. Construction of Relational Topographies from the Quantitative Measurements of Functional Deep Brain Stimulation Using A "Roving Window" Interpolation Algorithm. Stereotact Funct Neurosurg 2010;88:16-23 (DOI: 10.1159/000260075)
Marks, WJ, Bartus RT, Siffert J, Davis CS, Lozano A, Boulis N, Vitek J, Stacy M, Turner D, Verhagen L, Bakay R, Guthrie BL, Jankovich J, Simpson R, Yagliati M, Alterman R, Stern M, Baltuch G, Starr P, Larson P, Ostrem JL< Nutt J, Kieburtz K, Kordower JH, Warren C. William J, Olanow. Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial. . www.thelancet.com/neurology, DOI:10.1016/S1474-4422(10), October 21, 2010
Walker HC, Watts, RL, Schrandt CJ, Huang H, Guthrie SL, Guthrie BL, Montgomery EB. Activation of Subthalamic Neurons by Contralateral Subthalamic Deep Brain Stimulation 4 in Parkinson Disease. J Neurophys. IN press, 2011
Shenai BS, Dillavou M, Shum C, Ross D, Tubbs S, Shih A, Guthrie B. Virtual Interactive Presence and Augmented Reality (VIPAR) for Remote Surgical Assistance. Neurosurgery 68[ONS Suppl 1] p200-7, 2011