 | Address: | Boshell Diabetes Building
Room 630
1808 7th Avenue South
Birmingham, AL 35294-0012 |
Telephone:
Fax:
E-Mail:
| (205) 934-4420
(205) 975-8079
segrest@uab.edu |
Recent Publications
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Lab Research Focus: Plasma Lipoprotein Structure/Function We utilize peptide analogs, site-directed mutagenesis and molecular modeling to study structure/function of apolipoproteins and to determine if the fusion domain of HIV is a novel-? wedge structure. Additional research includes: inhibition of viral fusion by apolipoprotein analogs, structural studies of the cytotoxic and antibacterial activities of lytic peptides, and analyzing the properties of lipoproteins isolated from human atherosclerotic plaque.
Biography
Dr. Segrest, who developed the theory of the amphipathic helix, joined UAB in 1974. He is a Professor of Medicine and Director of the Atherosclerosis Research Unit and is currently supported by grants from NIH.s