Date Completed: 1/14/09
Faculty Name: Randall S. Davis
UAB Department: Medicine
UAB School: Medicine
Campus Address: SHEL 412
Campus Zip: 2182
Telephone: 934-1522
Email Address: rsdavis@uab.edu
Office Fax: 934-1875
Research Program Area: Cancer Cell Biology
Project Title: Biological Role of Fc Receptor-Like Molecules
Project Status: Already up-and-running
Proposed Start Date: April 13
Proposed End Date: August 28
Number of Weeks of Internship: 16
Number of Interns: 2
Other faculty, staff, or graduate students who may help supervise intern: Michael Alberti
Expected Number of Work Hours Per Week: 37.5 hours
Expected Work Schedule for Intern: Flexible, intern can largely set his or her own schedule
Number of hours that preceptor will personally supervise or work with intern: 2-4
Category of Research: Laboratory Research
Cancer Research: Genetics; Leukemia/Blood
Project Description: Dr. Davis' laboratory is focused on investigating the fundamental pathways of lymphoid development in order to explore the mechanisms that contribute to lymphomagenesis. An interest in molecular aspects of hematopoietic malignancies, led to the co-discovery of a novel family of Ig-like superfamily genes from the human chromosome 1q21-23 region provisionally termed Fc receptor-like molecules (FCRL1-5). FCRL family members are preferentially expressed by B lymphocytes and differentially identified in B lineage malignancies and autoimmune disorders. Follow-up studies have identified eight human and seven mouse relatives. The recognition of this family had significant implications for understanding connections between innate and adaptive humoral immunity, the regulation and terminal differentiation of B cells, and, the pathogenesis of B cell malignancies and autoimmunity.
Intern's Anticipated Duties:
Duty 1: Performing bench science experiments - molecular biology and cell biology
Preceptor will provide intern with access to the following: office or desk space; computer and printer; laboratory work bench space; equipment needed to complete project; supplies needed to complete project
Likelihood of authoring publications: Possible
Background, education, experience, or expertise preferred: Cell Biology; Biochemistry; Genetics; Basic Knowledge of Lab Skills; Immunology; Literature Review Skills; Molecular Biology
This faculty member has been a CaRES Preceptor for one summer.
Intern 1: Matthew Hull Intern 2: Jason Harrison